H-Y antigens as Y chromosome-encoded gene products and serologically detectable male antigens (SDM) as testis- or spermatogenesis-linked autosomal gene products

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H-Y antigens as Y chromosome-encoded gene products and serologically detectable male antigens (SDM) as testis- or spermatogenesis-linked autosomal gene products

', Research Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science & Technology, Central 6, 1-1-1 lligashi, Tsukuba, Ibaraki 305-8566, Japan; *, Itoham Central Research Institute, 1-2 Kubogaoka, Moriya, Kitasoma, Ibaraki 302-0104, Japan; ', Kanagawa Cancer Research Institute, Nakao 1-1-2, Asahi-ku, Yokohama 241-0815, Japan; ', Nalional Institute of Livestock ...

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Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome.

The acquisition of autosomal fertility genes has been proposed to be an important process in human Y chromosome evolution. For example, the Y-linked fertility factor DAZ (Deleted in Azoospermia) appears to have arisen after the transposition and tandem amplification of the autosomal DAZH gene. The Drosophila melanogaster Y chromosome contains tandemly repeated Su(Ste) units that are thought to ...

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Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila.

The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes. Nonetheless, natural variation on the Y chromosome in Drosophila melanogaster has substantial trans-acting effects on the regulation of X-linked and autosomal genes. However, the contribution of Y chromosome divergence to gene expression divergence between species is unknown. In this study, we co...

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Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis.

During spermatogenesis, spermatogonial stem cells, undifferentiated and differentiated spermatogonia, spermatocytes, spermatids and spermatozoa all express specific antigens, yet the functions of many of these antigens remain unexplored. Studies in the past three decades have shown that many of these transiently expressed genes in developing germ cells are proto-oncogenes and oncogenes, which a...

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Over-Expressed Testis-Specific Protein Y-Encoded 1 as a Novel Biomarker for Male Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a male-predominant cancer. Previous studies have focused on the sex-related disparity in HCC, but the underlying mechanism remains unclear. Here, we aimed to discover characteristic biomarkers for male HCC. Clinical samples were subjected to iTRAQ labeling followed by 2DLC-ESI-MS/MS analysis. Seventy-three differential proteins containing 16 up-regulated and 57...

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ژورنال

عنوان ژورنال: Archives Animal Breeding

سال: 2001

ISSN: 2363-9822

DOI: 10.5194/aab-44-677-2001